Harrison's Principles Of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2) 20Th Edition

Introducing the Landmark Twentieth Edition of the Global Icon of Internal Medicine     The definitive guide to internal medicine is more essential than ever with the latest in disease mechanisms, updated clinical trial results and recommended guidelines, state-of-the art radiographic images, therapeutic approaches and specific treatments, hundreds of demonstrative full-color drawings, and practical clinical decision trees and algorithms   Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison’s Principles of Internal Medicine gives you the informational foundation you need to provide the best patient care possible. Trusted by generations of students and clinicians, this cornerstone two-volume text maintains its accessible, standard-setting balance between the scientific foundations of signs and symptoms, and the clinical management of the patient. This 20th edition is more relevant—and essential—than ever, with a refreshed, user-friendly design and cutting-edge new content that reflects the latest foundational, bioscientific, and clinical insights across the full spectrum of medicine.       Essential for practice and education, the landmark 20th Edition features:    •Thoroughly revised content—covering the many new breakthroughs and advances in clinical medicine that have occurred since the last edition of Harrison’s. Chapters on acute and chronic hepatitis, management of diabetes, immune-based therapies in cancer, multiple sclerosis, cardiovascular disease, HIV, and many more, deliver the very latest information on disease mechanisms, diagnostic options, and the specific treatment guidance you need to provide optimal patient care.   •State-of-the-art coverage of disease mechanisms: Harrison’s focuses on pathophysiology with rigor, and with a goal of linking disease mechanisms to treatments. Improved understanding of how diseases develop and progress not only promotes better decision-making and higher value care, but also makes for fascinating reading and improved retention. Harrison’s summarizes important new basic science developments, such as the role of mitochondria in programmed and necrotic cell death, the immune system’s role in cancer development and treatment, the impact of telomere shortening in the aging and disease processes, and the role of the microbiome in health and disease. Understanding the role of inflammation in cardiovascular disease, the precise mechanisms of immune deficiency in HIV/AIDS, prions and misfolded proteins in neurodegenerative diseases, and obesity as a predisposition to diabetes are just a few examples of how this edition provides essential pathophysiology information for health professionals.   •All-new sections covering a wide range of new and emerging areas of vital interest to all healthcare professionals. New sections include: Sex and Gender-based Issues in Medicine; Obesity, Diabetes Mellitus, and Metabolic Syndrome; and Consultative Medicine—and contain knowledge-building chapters on increasingly vital, fast-evolving areas of medical science and clinical medicine. Plus, a new Part covering cutting edge topics in research and clinical medicine includes great new chapters on the role of Epigenetics in Health and Disease, Behavioral Strategies to Improve Health, Genomics and Infectious Diseases, Emerging Neuro-Therapeutic Technologies, and Telomere Function in Health and Disease, and Network System Medicine.   •Important and timely new chapters—such as Promoting Good Health, LGBT Heal